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Can RSO Make You Vomit? – Learn The Causes

If you’re considering using Rick Simpson Oil (RSO) for its potential health benefits, it’s crucial to understand its effects fully. One question that often arises is: “Can RSO make you vomit?” 

It’s understandable, as no one wants to exchange one set of problems for another. While the use of RSO can lead to therapeutic benefits, it’s essential to understand that it may also cause side effects like nausea, vomiting, and dizziness.

Yes, RSO can potentially cause vomiting along with other side effects, such as nausea and dizziness. However, these effects can significantly vary based on the individual’s tolerance and the dosage used. Therefore, it’s crucial to consult with a medical professional before using RSO or any other cannabis-based products.

Can RSO Make You Vomit? – Brief Answer

Indeed, the use of Rick Simpson Oil can lead to vomiting in some cases. It’s primarily due to the high concentration of THC in RSO, which can overstimulate the endocannabinoid system in our bodies when consumed in large doses. 

This overstimulation can disrupt the system’s normal functioning, leading to adverse reactions like vomiting. 

However, it’s important to remember that these reactions can significantly differ based on individual tolerance and dosage. 

So, while some people might experience these side effects, others may not. This underlines the importance of starting with a low dose, especially for new users, and gradually increasing the dosage under medical supervision.

What is RSO?

Rick Simpson Oil (RSO) is a cannabis-derived oil named after its creator, Rick Simpson. Known for its potent concentration of the cannabinoid THC, it has gained significant attention for its potential therapeutic properties.

RSO is often considered a type of medical marijuana used by patients seeking relief from ailments like pain, insomnia, and even more severe conditions like cancer.

At its core, RSO is a highly concentrated extract of cannabis, with its primary active compound being THC (tetrahydrocannabinol). This compound interacts with the body’s endocannabinoid system, regulating numerous physiological processes.

However, RSO also contains other cannabinoids, terpenes, and phytochemicals that may contribute to its overall therapeutic effects.

Medical Applications of RSO

The potential health benefits of RSO are vast, primarily due to its high THC concentration.

It’s utilized by patients suffering from various conditions, such as chronic pain, insomnia, and inflammation.

Some research also suggests potential benefits for individuals with neurodegenerative diseases, cancer, and certain mental health conditions like PTSD.

Scientific research into RSO’s effectiveness is still relatively new, but early studies and anecdotal evidence have shown promising results.

Some research suggests THC can help alleviate chronic pain, improve sleep quality, and may even inhibit the growth of certain cancer cells.

However, it’s crucial to remember these studies are preliminary, and more comprehensive research is needed.

Can RSO Lead to Nausea and Vomiting?

Although RSO can potentially provide relief for various conditions, like any potent therapeutic agent, it can also cause side effects. Nausea and vomiting are among these potential side effects.

While it might seem paradoxical since cannabis is also used to treat nausea, high doses of THC, as found in RSO, can induce nausea and vomiting in some individuals, a condition known as cannabinoid hyperemesis syndrome.

Reasons Behind These Side Effects

The side effects experienced when using RSO, such as vomiting and nausea, are closely linked to the interaction of THC, the active compound in RSO, with the endocannabinoid system within our bodies. The endocannabinoid system plays a crucial role in maintaining several physiological processes, including mood regulation, immune response, and pain management.

When you consume RSO, the THC present in the oil binds to the cannabinoid receptors found within this system, namely CB1 and CB2 receptors. These receptors are located in various parts of the body, including the brain and the digestive system. The binding of THC to these receptors can induce a variety of effects.

  • Low THC Concentration: When THC is consumed in low concentrations, it can provide beneficial effects such as pain relief, appetite stimulation, and even a reduction in nausea. This is why medical cannabis is often used to manage chemotherapy-induced nausea and vomiting.
  • High THC Concentration: However, when consumed in higher doses, as is the case with RSO, THC can overstimulate the cannabinoid receptors, especially those in the brain and the gut. This overstimulation can disrupt the normal functioning of the endocannabinoid system and lead to adverse reactions, such as vomiting and nausea. This condition is referred to as cannabinoid hyperemesis syndrome.
  • Research on THC Interaction: The complex interaction of THC with our endocannabinoid system is a topic of extensive scientific research. Despite the current understanding, there is much more to learn about how different concentrations of THC influence our bodily functions and cause side effects.

It’s crucial to note that reactions to RSO can vary greatly among individuals, largely due to differences in tolerance and dosage. For some, a small amount of RSO might lead to unwanted side effects, while others may need larger doses to experience any effect.

Individual Tolerance and Dosage: A Key to Side Effects

Individual tolerance and dosage are two critical factors that determine how a person will react to RSO. Tolerance refers to how much cannabis a person can consume before experiencing any negative effects. Over time, regular users may develop a higher tolerance, meaning they need larger doses to achieve the same effects.

Factors Influencing Individual Tolerance Levels

The effect of RSO, like any other cannabis product, varies greatly among individuals. This variation can be attributed to a person’s individual tolerance level. This tolerance level essentially determines how much THC an individual can consume before experiencing adverse effects. The tolerance level is influenced by several factors:

  • Frequency of Use: Regular users of cannabis products, including RSO, often develop a higher tolerance level. This means they can consume higher doses of THC without experiencing adverse effects. On the other hand, new or occasional users may experience side effects even at lower doses.
  • Body Composition: Factors such as body mass index (BMI), metabolic rate, and overall health status can influence an individual’s tolerance to THC. For instance, individuals with a higher BMI may require larger doses due to the fat-soluble nature of THC.
  • Genetic Factors: Genetics also play a significant role in determining an individual’s tolerance level. Some people may be genetically predisposed to be more sensitive to THC, leading to side effects even at smaller doses.
  • Interactions with Other Substances: The use of other substances, such as alcohol or prescription medications, can also affect an individual’s tolerance to THC. These substances can either increase or decrease the effects of THC, potentially leading to adverse reactions.

In summary, understanding the factors influencing individual tolerance levels can help manage and prevent potential side effects when using RSO. It’s always advisable to start with a low dose and gradually increase it under the guidance of a healthcare professional to ensure the safe and beneficial use of RSO.

Importance of Medical Consultation Before Using RSO

Given the potential side effects of RSO, including nausea and vomiting, it’s essential to consult with a healthcare professional before starting any regimen involving RSO.

A qualified healthcare provider can provide guidance on dosage and monitor any potential side effects, ensuring safe and beneficial use of the product.

Self-medication with cannabis-based products, including RSO, carries significant risks, particularly due to the potential for adverse reactions and interactions with other medications.

Misuse can lead to severe side effects, including excessive sedation, anxiety, and even dependence. Hence, medical consultation is not just beneficial, it’s crucial.

How to Mitigate the Side Effects of RSO

The side effects of RSO, such as vomiting, can be uncomfortable and concerning, especially for new users. However, there are several strategies to manage and reduce these side effects.

  • Start with Low Doses: The first and foremost advice to mitigate the side effects of RSO is to start with small doses. This allows your body to gradually adjust to the effects of THC, thereby reducing the likelihood of experiencing side effects.
  • Gradually Increase Dosage: Once your body has adjusted to the lower dose, you can gradually increase the amount over time. This method, known as “titration,” helps prevent the overstimulation of the endocannabinoid system.
  • Maintain Hydration: Vomiting can lead to dehydration. Hence, it’s important to stay well-hydrated by drinking plenty of fluids. Hydration can also help reduce the intensity of other side effects like dry mouth and dizziness.
  • Rest and Relaxation: Rest is crucial when experiencing side effects from RSO. Resting can help your body recover and deal with the side effects more efficiently. Try to ensure you’re in a calm, comfortable environment to manage any anxiety or restlessness.
  • Seek Medical Help: If side effects persist or worsen, it’s important to seek medical attention. Healthcare professionals can provide advice and potential treatment to manage the side effects of RSO.

Other Potential Side Effects of RSO

While vomiting, nausea, and dizziness are common side effects associated with RSO, it’s worth noting that there are several other potential side effects users should be aware of:

  • Psychological Effects: High doses of THC in RSO can lead to a range of psychological effects, including anxiety, paranoia, and hallucinations. These effects are generally temporary but can be distressing.
  • Dry Mouth and Eyes: THC can interfere with the production of saliva and tears, leading to conditions commonly known as “cottonmouth” and dry eyes. These are relatively mild side effects but can be uncomfortable.
  • Increased Heart Rate: THC can stimulate the cardiovascular system, leading to an increased heart rate. This can be concerning for individuals with pre-existing heart conditions.
  • Impaired Motor Control and Coordination: RSO can affect motor skills and reaction times. This means tasks that require concentration, such as driving, can be dangerous after consuming RSO.
  • Changes in Appetite: RSO can lead to changes in appetite, causing either increased hunger (often known as the “munchies”) or reduced appetite.

Knowing these potential side effects helps users to be better prepared and respond appropriately. It also underlines the importance of starting with a low dose, especially for new users and seeking medical advice if any concerning symptoms occur.


In conclusion, while RSO offers potential health benefits, it’s crucial to be aware of the possible side effects, including vomiting. 

These side effects can be managed by starting with a low dose, gradually increasing the dosage, staying hydrated, resting, and seeking medical help when necessary. 

Remember that individual reactions to RSO can vary widely due to factors like frequency of use, body composition, genetics, and interactions with other substances. 

Hence, it’s crucial to consult with a healthcare professional before beginning RSO or any other cannabis-based treatment to ensure a safe and beneficial experience.


1. How can I manage vomiting caused by RSO?

To manage vomiting caused by RSO, start with a low dose and gradually increase it over time. Staying well-hydrated and resting can also help manage the side effects. Always consult with a medical professional if side effects persist.

2. Does everyone who uses RSO experience vomiting?

Not everyone who uses RSO will experience vomiting. Reactions to RSO can vary widely based on individual tolerance and dosage. Some people might experience side effects, while others may not.

3. Can I reduce the risk of vomiting from RSO by adjusting my dosage?

Yes, starting with a low dose of RSO and gradually increasing it can help reduce the risk of vomiting and other side effects. The process, known as “titration,” helps prevent overstimulation of the endocannabinoid system.

4. What are some other potential side effects of RSO aside from vomiting?

Besides vomiting, RSO can cause side effects like nausea, dizziness, psychological effects such as anxiety, dry mouth and eyes, increased heart rate, impaired motor control and coordination, and changes in appetite.


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